Endocrine Abstracts

Recent integrative approaches showed that adipose tissue play a major endocrine role. Molecules secreted by the expanding adipose tissue modulate systemic inflammation and contribute heavily to the pathology of obesity co-morbidities. Acylation stimulating protein (ASP) is an adipokine that has been linked with energy metabolism and lipid metabolism. The ASP receptor, C5L2, is widespread within tissues in the organism, yet ASP effects outside the adipose tissue remain explored...

Recently, several groups have described a subset of obese women, who despite having excessive total body fat, are insulin sensitive (ISO for Insulin Sensitive Obese), normotensive and present a favorable lipid profile. Adiponectin, ghrelin and leptin play important roles in the regulation of energy metabolism and food intake. Moreover, all three hormones have been reported to be closely linked to insulin resistance and regulated by insulin. Therefore, we propose to investigate...